WIKIPEDIA kertoo, että ihmisellä on kahdeksan elastaasigeeniä. ( Tämä artikkeli on keskeneräinen)
Mikä näistä olisi kyseessä aortan aneurysmissa?
( Ainakin MMP-9 erään lähteen mukaan. http://www.chisholm.northwestern.edu/chisholm/MMP9.htm )
Wikipedialähde maintisee että myös MMP-12 osallistuu aneurysman muodostukseen. (MMP12 may play a role in aneurysm formation[4] and studies in mice and humans suggest a role in the development of emphysema).
http://en.wikipedia.org/wiki/Neutrophil_elastase
Interactions Neutrophil elastase has been shown to interact with Alpha 2-antiplasmin.
There exist eight human genes for elastase:
Family | Gene symbol | Protein name | EC number | ||
---|---|---|---|---|---|
Approved | Previous | Approved | Previous | ||
chymotrypsin- like | CELA1 | ELA1 | chymotrypsin-like elastase family, member 1 | elastase 1, pancreatic | EC 3.4.21.36 |
CELA2A | ELA2A | chymotrypsin-like elastase family, member 2A | elastase 2A, pancreatic | EC 3.4.21.71 | |
CELA2B | ELA2B | chymotrypsin-like elastase family, member 2B | elastase 2B, pancreatic | EC 3.4.21.71 | |
CELA3A | ELA3A | chymotrypsin-like elastase family, member 3A | elastase 3A, pancreatic | EC 3.4.21.70 | |
CELA3B | ELA3B | chymotrypsin-like elastase family, member 3B | elastase 3B, pancreatic | EC 3.4.21.70 | |
chymotrypsin | CTRC | ELA4 | chymotrypsin C (caldecrin) | elastase 4 | EC 3.4.21.2 |
neutrophil | ELANE | ELA2 | neutrophil elastase | elastase 2 | EC 3.4.21.37 |
macrophage | MMP12 | HME | macrophage metalloelastase | macrophage elastase | EC 3.4.24.65 |
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