ADAM10: ADA10 Geeni Uutiset

Entrez Gene summary for ADAM10 Gene:

Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. (provided by RefSeq, Jul 2008) GeneCards Summary for ADAM10 Gene:  ADAM10 (ADAM metallopeptidase domain 10) is a protein-coding gene. Diseases associated with ADAM10 include anoxia, and amyloidosis, and among its related super-pathways are Parkinson's disease and Constitutive Signaling by NOTCH1 PEST Domain Mutants. GO annotations related to this gene include protein kinase binding and protein homodimerization activity. An important paralog of this gene is ADAM17. UniProtKB/Swiss-Prot: ADA10_HUMAN, O14672 Function: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala- -Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasLAPL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling Gene Wiki entry for ADAM10 Gene