ADAM10 proteaasin kypsyminen alfasekretaasiksi

http://www.fasebj.org/content/15/10/1837.full?ijkey=3d65722badc2bc2cc1b29e4cf2f9c7b3ff2b2318&keytype2=tf_ipsecsha
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published online June 27, 2001 as 10.1096/fj.01-0007fje.  
ANDREAS ANDERS, SANDRA GILBERT, et al.Regulation of the α-secretase ADAM10 by its prodomain and proprotein convertases¹

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Figure 3.

Model for regulation of APP processing by proprotein convertases via proteolytical activation of the α-secretase ADAM10 and the β-secretase BACE. The prodomain of ADAM10 is necessary for the correct folding and maintains the proteinase in a latent state. Prodomain removal results in the activation of the zymogen ADAM10.

 In contrast, the prodomain of BACE is cleaved by furin but not by PC7. Arrows indicate consecutive steps in proteinase maturation and function whereby subcellular compartments are not considered.