MT2A Metallotioneiini 2A suojaa raskasmetalleilta ja vapailta radikaaleilta, säätelee solusinkkiä. Eduksi on tupakanpolton lopetus,jolloin rasite puolustukselle vähenee.

 https://reactome.org/PathwayBrowser/#/R-HSA-5660526

MT2A geeni 

• This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions, altering the intracellular concentration of heavy metals in the cell. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. The encoded protein interacts with the protein encoded by the homeobox containing 1 gene in some cell types, controlling intracellular zinc levels, affecting apoptotic and autophagy pathways. Some polymorphisms in this gene are associated with an increased risk of cancer. [provided by RefSeq, Sep 2017]

• Gene Families for MT2A Gene

  HGNC:

  • Metallothioneins

  The Human Protein Atlas (HPA):

  • Plasma proteins
   
  • Predicted intracellular proteins

  Protein Domains for MT2A Gene

  InterPro:

  • Metalthion_dom_sf 
   
  • Metalthion_dom_sf_vert 
   
  • Metalthion_vert 
   
  • Metalthion_vert_metal_BS

  Blocks:

  • Growth factor cystine knot superfamily signature

  Suggested Antigen Peptide Sequences for MT2A Gene

  GenScript: Design optimal peptide antigens:

  • Metallothionein-II (MT2_HUMAN)

  Graphical View of Domain Structure for InterPro Entry

   P02795

  UniProtKB/Swiss-Prot:

   MT2_HUMAN :

  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
   
  • Belongs to the metallothionein superfamily. Type 1 family.

  Domain:

  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

  Family:

  • Belongs to the metallothionein superfamily. Type 1 family.

  • Protein details for MT2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:

     

    P02795-MT2_HUMAN

     

    Recommended name:

     

    Metallothionein-2

    Protein Accession:

     

    P02795

    Secondary Accessions:

     

    • Q14823
     
    • Q2HXR9
     
    • Q53XT9

    Protein attributes for MT2A Gene

    Size:

    61 amino acids

    Molecular mass:

    6042 Da

    Protein existence level:

    PE1

    Quaternary structure:

    
    

    • Interacts with EOLA1.

    Miscellaneous:

    
    

    • This metallothionein binds zinc.

    Three dimensional structures from PDB (representative) and AlphaFold (predicted) for MT2A Gene

• 
  

22

MT2A

Metallothionein 2A

Protein Coding

P02795

56

GC16P137359

4.87