ADAMTS9 (Kromosomi 3). ADAMTS9 omaa osuutta 2-tyypin diabeteksen etiologiassa

 17.11. 2016  Löydän ADAM-TS9 geenin  taulukosta, jossa luetellaan  tyypin 2 Diabeteksen   etiopatogeneesiin assosioituvat   21  havaittua geeniä. Maininta on   kirjasta Claes Göran Östenson. (toim) Diabetes typ 2.  (2015)  professori H Mulberin artikkelista kappaleessa  Come-back för beta-cellen i diabetespatogenesen , taulukossa sivulla 26. neljäntenätoista geeninä 21:stä mainitaan "ADAMTS9, ADAM metallopetidase with thrombospondin type 1 motif, 9. Function: Growth. Tillväxt.

28.12. 2912 
http://www.sciencedirect.com/science/article/pii/S0888754300962463

Abstract

ADAM-TS/metallospondin genes encode a new family of proteins with structural homology to the ADAM metalloprotease-disintegrin family.

 However, unlike other ADAMs, these proteins contain thrombospondin type 1 (TSP1) repeats at the carboxy-terminal end and are secreted proteins instead of being membrane bound.

Members of the ADAM-TS family have been implicated

• in the cleavage of proteoglycans,
•  the control of organ shape during development, 
• and the inhibition of angiogenesis.
•  We have cloned a new member of the ADAM-TS/metallospondin family designated here as ADAMTS9. This protein has a metalloprotease domain, a disintegrin-like domain, one internal TSP1 motif, and three carboxy-terminal TSP1-like submotifs. 
•  In contrast to other ADAM-TS family members, ADAMTS9 is expressed in all fetal tissues examined as well as some adult tissues.
•  Using FISH and radiation hybrid analysis, we have localized ADAMTS9 to chromosome 3p14.2–p14.3, an area known to be lost in hereditary renal tumors.
•