Pre-angiotensinogen Geeni AGT, sijainti :kromosomi 1q42.2.

 Angiotensinogen AGT kromosomi 1q42.2.

Summary

Official Symbol

AGTprovided by HGNC

Official Full Name

angiotensinogenprovided by HGNC

Primary source

HGNC:HGNC:333

See related

Ensembl:ENSG00000135744 HPRD:00106; MIM:106150; Vega:OTTHUMG00000037757

Gene type

protein coding

RefSeq status

REVIEWED

Organism

Homo sapiens

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Also known as

ANHU; SERPINA8

Summary

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008]

Related articles in PubMed

1. Cardiac angiotensin-(1-12) expression and systemic hypertension in rats expressing the human angiotensinogen gene. Ferrario CM, et al. Am J Physiol Heart Circ Physiol, 2016 Apr 15. PMID 26873967,
2. Possible role for nephron-derived angiotensinogen in angiotensin-II dependent hypertension. Ramkumar N, et al. Physiol Rep, 2016 Jan. PMID 26755736, Free PMC Article
3. Renin-Angiotensin System Gene Variants and Type 2 Diabetes Mellitus: Influence of Angiotensinogen. Joyce-Tan SM, et al. J Diabetes Res, 2016. PMID 26682227, Free PMC Article
4. Assessment of urinary angiotensinogen as a marker of podocyte injury in proteinuric nephropathies. Eriguchi M, et al. Am J Physiol Renal Physiol, 2016 Feb 15. PMID 26632605
5. Angiotensin II status and sympathetic activation among hypertensive patients in Uganda: a cross-sectional study. Mayito J, et al. BMC Res Notes, 2015 Oct 20. PMID 26486596, Free PMC Article

See all (975) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. Ang II induces cardiac fibrosis by enhancing DDR2 expression in cardiac fibroblasts via p38 MAPK-mediated activation of NF-kappaB.
2. Polymorphisms of three genes (ACE, AGT and CYP11B2) in the renin-angiotensin-aldosterone system are not associated with blood pressure salt sensitivity. (Meta-analysis)
3. There was an association between the AGT rs699 polymorphism and diabetes mellitus type 2 in the Brazilian patients.
4. Results indicate that urinary angiotensinogen was associated with blood pressure elevation in this population of obese young adults.
5. our analysis revealed that the associations of the AGT variants with T2DM were independently associated.
6. The M allele of M235T might be associated with an increased risk of atrial fibrillation recurrence after catheter ablation.
7. The urinary angiotensinogen level correlates with the overall maturity of renal function during the early postnatal period in critically ill neonates.
8. the association of polymorphisms in angiotensinogen (AGT) and angiotensin II type 1 receptor (AGTR1), with blood lead levels and lead-related blood pressure in lead-exposed male workers in Korea, was investigated.
9. the AGT polymorphisms have played a vital role in determining an individual's susceptibility to essential hypertension.
10. There were significant differences in genotype and allele distributions of ACE gene rs4343 (pgentoype = 0.002 and pallele < 0.001) and AGTR1 gene rs5186 polymorphisms.

Pathways from BioSystems

• ACE Inhibitor Pathway, organism-specific biosystem (from WikiPathways)
• Adipogenesis, organism-specific biosystem (from WikiPathways)
• Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
• Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
• G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
• G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
• GPCR downstream signaling, organism-specific biosystem (from REACTOME)
• GPCR ligand binding, organism-specific biosystem (from REACTOME)
• Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
• Metabolism, organism-specific biosystem (from REACTOME)
• Metabolism of Angiotensinogen to Angiotensins, organism-specific biosystem (from REACTOME)
• Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
• Metabolism of proteins, organism-specific biosystem (from REACTOME)
• MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
• Monoamine Transport, organism-specific biosystem (from WikiPathways)
• PPARA activates gene expression, organism-specific biosystem (from REACTOME)
• Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
• Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
• Physiological and Pathological Hypertrophy of the Heart, organism-specific biosystem (from WikiPathways)
• Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
• Renin secretion, organism-specific biosystem (from KEGG)
• Renin secretion, conserved biosystem (from KEGG)
• Renin-angiotensin system, organism-specific biosystem (from KEGG)
• Renin-angiotensin system, conserved biosystem (from KEGG)
• Signal Transduction, organism-specific biosystem (from REACTOME)

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