TIMP-1 geeni sijaitsee X-kromosomissa

https://www.ncbi.nlm.nih.gov/gene/7076
Aikanaan kun katselin  MMP-proteinaasien  aktivoitumisen kaskadia ja sitten sitä inhibitioreittiä TIMPs, siinä oli jollain tavalla puutteellista  karttakohtaa. Mikä  säätelee  negatiivisesti TIMP-inhibiittorit?

Näyttää olevan  paljon pahaa tästä TIMP-ylössäätymisestä kudoksissa:

TIMP-1 

Also known as

EPA; EPO; HCI; CLGI; TIMP; TIMP-1

Summary

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]

Expression

Broad expression in appendix (RPKM 344.6), gall bladder (RPKM 211.2) and 15 other tissues See more