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tisdag 22 juli 2014

Kyynmyrkyn hemorrhaginen metalloproteinaasi (HMP)


Kts. mys SVMP, Snake Venom Metalloprtoteinases,
Kyynpureman hoito nykyisellään.

 Artikkeli 14 vuoden takaa:
Comp Biochem Physiol C. 1990;97(2):209-14.Isolation and characterization of hemorrhagic metalloproteinase from Vipera berus  berus (common viper) venom.

Abstract

1. Hemorrhagic metalloproteinase (HMP) was isolated by gel filtration on a Sephadex G-100 (superfine) and affinity chromatography on agarose HPS-7.
 2. Hemorrhagic metalloproteinase is a glycoprotein with mol. wt 56.3 kDa. It contains 1 zinc atom per molecule of protein.
3. Hemorrhagic metalloproteinase hydrolyzes casein, fibrinogen and splits the insulin B chain at positions Ala14-Leu15, Tyr16-Leu17, His10-Leu11. It digests A alpha chain of fibrinogen.
PMID:
1982865
[PubMed - indexed for MEDLINE]
 

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