Kubelka CF, Azeredo EL, Gandini M, Oliveira-Pinto LM, Barbosa LS, Damasco PV, Avila CA, Motta-Castro AR, Cunha RV, Cruz OG.
J Infect. 2010 Dec;61(6):501-5. doi: 10.1016/j.jinf.2010.09.020. Epub 2010 Sep 21. No abstract available.
- PMID:
- 20863849
- [PubMed - indexed for MEDLINE]
2.
Voraphani N, Khongphatthanayothin A, Srikaew K, Tontulawat P, Poovorawan Y.
Jpn J Infect Dis. 2010 Sep;63(5):346-8.
The purpose of this study was to investigate the role of matrix metalloproteinase-9 (MMP-9) in the pathogenesis of vascular leakage in patients with dengue virus infection. Serum samples from 24 children with serologically confirmed dengue virus infection (dengue fever [DF], 16; dengue hemorrhagic fever [DHF], 8; age, 9.5+/-2.4 years; 67% male] were analyzed for MMP-9 during the febrile and toxic stages and at follow-up. Serum samples obtained from 7 healthy children were used as controls. Serum MMP-9 levels in patients with dengue virus infection were found to be lower at the febrile (227.0+/-186.9 ng/ml) and toxic stages (150.9+/-151.7 ng/ml) than at follow-up (424.5+/-227.8 ng/ml) or in the control group (393.3+/-125.9 ng/ml, P<0 p=""> In conclusion, MMP-9 levels are reduced during the febrile and toxic stages of dengue virus infection.
The purpose of this study was to investigate the role of matrix metalloproteinase-9 (MMP-9) in the pathogenesis of vascular leakage in patients with dengue virus infection. Serum samples from 24 children with serologically confirmed dengue virus infection (dengue fever [DF], 16; dengue hemorrhagic fever [DHF], 8; age, 9.5+/-2.4 years; 67% male] were analyzed for MMP-9 during the febrile and toxic stages and at follow-up. Serum samples obtained from 7 healthy children were used as controls. Serum MMP-9 levels in patients with dengue virus infection were found to be lower at the febrile (227.0+/-186.9 ng/ml) and toxic stages (150.9+/-151.7 ng/ml) than at follow-up (424.5+/-227.8 ng/ml) or in the control group (393.3+/-125.9 ng/ml, P<0 p=""> In conclusion, MMP-9 levels are reduced during the febrile and toxic stages of dengue virus infection.
- PMID:
- 20859002
- [PubMed - indexed for MEDLINE]
3.
Luplertlop N, Missé D.
Jpn J Infect Dis. 2008 Jul;61(4):298-301.
Dengue hemorrhagic fever and dengue shock syndrome, the major life-threatening outcomes of severe dengue disease, are the consequence of plasma leakage in the vascular areas. We previously demonstrated that dengue virus (DV)-infected dendritic cells (DC) trigger vascular leakage through matrix metalloproteinase (MMP)-9 overproduction, however little is known concerning the consequences of direct infection of macrovascular endothelial cells (MVEC) by DV.
In this study, we show that infection of primary human MVEC results in overproduction of MMP-2 and to a lesser extent of MMP-9, leading to enhanced endothelial permeability. This permeability was associated with loss of expression of the vascular endothelium-cadherin cell-cell adhesion.
The MMP response to DV infection is strikingly different between DC and MVEC. Therefore, our results demonstrated that endothelial cells are an important target for DV infection, and that DV-induced MMP-2 overproduction by direct infection of endothelial cells may contribute to the pathogenesis of severe dengue infection.
Dengue hemorrhagic fever and dengue shock syndrome, the major life-threatening outcomes of severe dengue disease, are the consequence of plasma leakage in the vascular areas. We previously demonstrated that dengue virus (DV)-infected dendritic cells (DC) trigger vascular leakage through matrix metalloproteinase (MMP)-9 overproduction, however little is known concerning the consequences of direct infection of macrovascular endothelial cells (MVEC) by DV.
In this study, we show that infection of primary human MVEC results in overproduction of MMP-2 and to a lesser extent of MMP-9, leading to enhanced endothelial permeability. This permeability was associated with loss of expression of the vascular endothelium-cadherin cell-cell adhesion.
The MMP response to DV infection is strikingly different between DC and MVEC. Therefore, our results demonstrated that endothelial cells are an important target for DV infection, and that DV-induced MMP-2 overproduction by direct infection of endothelial cells may contribute to the pathogenesis of severe dengue infection.
- PMID:
- 18653973
- [PubMed - indexed for MEDLINE]
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