28.12. 2912
http://www.sciencedirect.com/science/article/pii/S0888754300962463
Abstract
ADAM-TS/metallospondin
genes encode a new family of proteins with structural homology to the
ADAM metalloprotease-disintegrin family.
However, unlike other ADAMs, these proteins contain thrombospondin type 1 (TSP1) repeats at the carboxy-terminal end and are secreted proteins instead of being membrane bound.
Members of the ADAM-TS family have been implicated
However, unlike other ADAMs, these proteins contain thrombospondin type 1 (TSP1) repeats at the carboxy-terminal end and are secreted proteins instead of being membrane bound.
Members of the ADAM-TS family have been implicated
- in the cleavage of proteoglycans,
- the control of organ shape during development,
- and the inhibition of angiogenesis.
- We have cloned a new member of the ADAM-TS/metallospondin family designated here as ADAMTS9. This protein has a metalloprotease domain, a disintegrin-like domain, one internal TSP1 motif, and three carboxy-terminal TSP1-like submotifs.
- In contrast to other ADAM-TS family members, ADAMTS9 is expressed in all fetal tissues examined as well as some adult tissues.
- Using FISH and radiation hybrid analysis, we have localized ADAMTS9 to chromosome 3p14.2–p14.3, an area known to be lost in hereditary renal tumors.
