MMP-28 (15q21.1) Epilysiini

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810947/

Epilysin (MMP-28) was first cloned from the human keratinocyte and testis cDNA libraries, and is expressed in many tissues such as lung, placenta, heart, gastrointestinal tract and testis (Lohi et al., 2001). The enzyme expressed in basal keratinocytes in skin is considered to function in wound repair (Saarialho-Kere et al., 2002). It is also elevated in cartilage from patients with osteoarthritis and rheumatoid arthritis (Kevorkian et al., 2004; Momohara et al., 2004). Overexpression of recombinant MMP-28 in lung adenocarcinoma cells induces irreversible epithelial mesenchymal transition, accompanied by cell surface loss of E-cadherin, processing of latent TGFβ complex and increased levels of TGFβ, along with up-regulation of MT1-MMP and MMP-9 and collagen invasive activity (Illman et al., 2006).