Tetrasykliini estää kollagenaastyypin MMP proteinaaseja. Hyvä muistaa!.

http://allie.dbcls.jp/pubmed_all/MMPs;matrix+metalloproteinases.html
Agents Actions. 1993 Sep;40(1-2):124-8.

Effect of tetracyclines which have metalloproteinase inhibitory capacity on basal and heparin-stimulated bone resorption by chick osteoclasts.

Chowdhury MH¹, Moak SA, Rifkin BR, Greenwald RA. Abstract

Several tetracyclines (TETs) are potent inhibitors of collagenase (CGase) and can inhibit connective tissue degradation in a variety of inflammatory and degenerative disorders. The role of CGase in bone resorption by osteoclasts (OC) remains unclear. Disaggregated OCs from chick embryos were cultured for 24 h on devitalized bovine cortical bone +/- heparin in the presence of various TETs. Doxycycline (Dox) inhibited pit formation in a dose-dependent manner. CMT, a TET derivative which inhibits matrix metalloproteinases (MMPs) but is not antimicrobial, also inhibited chick OC bone resorption. Heparin markedly stimulated bone resorption at 5 micrograms/ml, which was reversed by Dox, 5 micrograms/ml. TETs can reversibly inhibit both basal and heparin-stimulated bone resorption by chick OCs. These findings suggest that MMPs may play a role in osteoclastic bone resorption, and that safe and effective inhibitors of MMPs, including certain TETs, might have a potential therapeutic role.

Muistiin 21.4. 2014
 Tämä on hyvä pitää mielessä, kun esiintyy  sellaisia infektioita joiita karakterisoi sytokiinimyrksy ja MMP-proteinaasien   laviini. Tässä mainitaan myös  TC johdos joka ei ole  edes antibioottinenkaan,  vaikuttaa samaa kollagenaasi-inhibiitiota.