Bourghardt Peebo, Beatrice. Angiogenesis from a new perspective Linköpings universitet Institutionen för klinisk och experimentell medicin. Oftalmologi.
Abstract
Subject headings- ISBN 978-91-7519-999-3
- Linköping : Linköping University Electronic Press, 2012
- English 91 s.
- Series: Linköping University Medical Dissertations, 0345-0082 ; 1284
- Read full text (fulltext)
- Doctoral thesis (other academic)
Background
Sitaatti:
Huomaa MMP ja TIMP joukossa.
Activators Function
- VEGF family members Stimulate vasculogenesis/angiogenesis, permeability, leukocyte adhesion
- Angiopoietin1, Tie2 Stabilize vessels, inhibit permeability
- PDGF Recruit pericytes, smooth muscle cells
- TGF-ß1, endoglin, TGF-ß-receptors Stimulate ECM production, recruit macrophages
- FGF, HGF, MCP1 Stimulate angio/arterogenesis
- Integrins Receptor for matrix macromolecules, proteinases
- VE-cadherin, PECAM (CD31) Endothelial junctional molecules
- Plasminogen activators, MMPs Remodel ECM, release and activate growth factors
- NOS-COX2 Stimulate angiogenesis and vasodilation
- HIF-1 Activates VEGF and other pro-angiogenic factors
Inhibitors Function
- VEGFR-1, soluble VEGFR-1, VEGFR-3 Sink for VEGF, PlGF
- Angiopoietin2 Antagonist for Angiopoietin1
- Trombospondin1,-2 Inhibit endothelial migration, growth, adhesion and survival
- Angiostatin Suppress tumor angiogenesis
- Endostatin (collagen XVIII fragment) Inhibit endothelial survival and migration
- TIMP InhibitsMMP
- IL-4, IL-12, IL-8, IFN-α,-ß,-ƴ Inhibit endothelial migration, down regulatebFGF
Table 1. Examples of activators and inhibitors of angiogenesis and their known func-
tions. (Carmeliet et al 2000)
