PubMed 107 vastausta. Sitaattina 10 tuoreinta.
109 results
ADAMTS5 Modulates Breast Cancer Development as a
Diagnostic Biomarker and Potential Tumour Suppressor, Regulated by
BAIAP2-AS1, CRNDE and hsa-miR-135b-3p: Integrated Systems Biology and
Experimental Approach.
IET Syst Biol. 2025 Jan-Dec;19(1):e70015. doi: 10.1049/syb2.70015.
PMID: 40472834
Free PMC article.
ADAMTS5, a member of the ADAMTS family, exhibits crucial biological roles, including protein shedding, proteolysis, and cell migration. ...
STAT-3, ELK-1, and c- Jun contributes IL-6 mediated ADAMTS-8 upregulation in colorectal cancer.
Mol Biol Rep. 2025 Feb 19;52(1):246. doi: 10.1007/s11033-025-10342-4.
PMID: 39969607
BACKGROUND: ADAMTSs are extracellular matrix
metalloproteinases that mainly process extracellular matrix components
and closely related tumorigenesis. ADAMTS-8 is an anti-angiogenic member of the family and is dysregulated in common cancers. ...STATs, Elk-1, and c-J …
Assessment of Methylation in Selected ADAMTS Family Genes in Non-Small-Cell Lung Cancer.
Int J Mol Sci. 2025 Jan 23;26(3):934. doi: 10.3390/ijms26030934.
PMID: 39940703
Free PMC article.
The methylation degree of promoter regions in genes encoding ADAMTS family
proteins could significantly influence LUSC and LUAD. Increased
promoter methylation could also reduce certain gene expression,
contributing to cancer progression. ...Further research is need …
ADAMTS7 Enhances Gastric Cancer Growth and Metastasis by Triggering the NF-κB Signaling Pathway.
J Cancer. 2025 Jan 1;16(3):1008-1019. doi: 10.7150/jca.103093. eCollection 2025.
PMID: 39781347
Free PMC article.
The ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family
of metalloproteinases plays a vital role in various biological and
pathological processes, including tissue remodeling, angiogenesis, and
cancer progression. Among the 19 ADAMTS …
ADAMTS16 drives epithelial-mesenchymal transition and
metastasis through a feedback loop upon TGF-β1 activation in lung
adenocarcinoma.
Cell Death Dis. 2024 Nov 17;15(11):837. doi: 10.1038/s41419-024-07226-z.
PMID: 39551781
Free PMC article.
The poor prognosis of LUAD patients is attributed primarily to metastasis. ADAMTS16 is a crucial member of the ADAMTS family and is involved in tumor progression. However, its role and regulatory mechanism in LUAD remain unexplored. ...
Multi-Omics Pan-Cancer Analysis of Procollagen N-Propeptidase Gene Family of ADAMTS as Novel Biomarkers to Associate with Prognosis, Tumor Immune Microenvironment, Signaling Pathways, and Drug Sensitivities.
Front Biosci (Landmark Ed). 2024 Apr 12;29(4):151. doi: 10.31083/j.fbl2904151.
PMID: 38682182
Free article.
The roles of another important group: the ADAMs with thrombospondin motifs (ADAMTS) remain unclear. This study aimed to perform a pan-cancer analysis of procollagen N-propeptidase subgroup of ADAMTS (PNPSA). ...Single-cell sequencing analysis reveals expressions of …
ADAMTS Gene-Derived circRNA Molecules in
Non-Small-Cell Lung Cancer: Expression Profiling, Clinical Correlations
and Survival Analysis.
Int J Mol Sci. 2024 Feb 5;25(3):1897. doi: 10.3390/ijms25031897.
PMID: 38339175
Free PMC article.
The present study examines the relationship between circular RNA (circRNA) derived from three genes of the family
a disintegrin and metalloproteinase with thrombospondin motifs
(ADAMTSs): ADAMTS6, ADAMTS9 and ADAMTS12 and the host gene expression in
non-small-cell lung can …
Determination of Versikine Levels by Enzyme-Linked Immunosorbent Assay (ELISA).
Methods Mol Biol. 2024;2747:83-93. doi: 10.1007/978-1-0716-3589-6_8.
PMID: 38038934
Metalloproteinases of the A Disintegrin and Metalloproteinase with Thrombospondin-like motif (ADAMTS) family
cleave versican at a specific Glu-Ala bond, thus releasing a bioactive
fragment named versikine, whose biological function, still not entirely
revealed, seem …
Expression and Purification of Recombinant ADAMTS8.
Methods Mol Biol. 2024;2747:55-66. doi: 10.1007/978-1-0716-3589-6_5.
PMID: 38038931
So far, the only reported substrate for ADAMTS8 is
osteopontin (OPN), an extracellular matrix protein widely implicated in
multiple steps of cancer progression, albeit, similar to other ADAMTS family members, it is very likely that ADAMTS8 cleaves a variety of subst …
ADAMTS-1 has nuclear localization in cells with epithelial origin and leads to decreased cell migration.
Exp Cell Res. 2023 Dec 15;433(2):113852. doi: 10.1016/j.yexcr.2023.113852. Epub 2023 Nov 10.
PMID: 37951335
Free PMC article.
However, our research specifically detected ADAMTS-1, a member of this family, predominantly within the nucleus of mammary cells. Our main objective was to understand the mechanism of ADAMTS-1 translocation to the nucleus and its functional significance in th …
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