MT-MMP proteiinit, erityisesti GPI-ankkuroidut . Mitä uutta? Kaksi MT-MMP proteiinia käyttää GPI-ankkuria.

 https://pubmed.ncbi.nlm.nih.gov/?term=MT-MMPs+++GPI+anchored+type&sort=date

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MMP matrixmetalloproteiinit ovat  sinkkijonista riippuvaisia endopeptidaaseja. MT-MMP perheenjäseniä on kuusi ja niistä kaksi käyttää GPI-ankkuria ja neljä  on  muulla tavalla  membraanityyppinen . typpisellä  ankkuroitumisella.MT4-MMP on  toiselta nimeltä MMP17. 

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1

Molecular Mechanisms Driven by MT4-MMP in Cancer Progression.

Muñoz-Sáez E, Moracho N, Learte AIR, Collignon A, Arroyo AG, Noel A, Sounni NE, Sánchez-Camacho C. Int J Mol Sci. 2023 Jun 9;24(12):9944. doi: 10.3390/ijms24129944. PMID: 37373092 Free PMC article. Review.

MT4-MMP (or MMP-17) belongs to the membrane-type matrix metalloproteinases (MT-MMPs), a distinct subset of the MMP family that is anchored to the cell surface, in this case by a glycosylphosphatidylinositol (GPI) motif. ...

2

Neoplastic Cells are the Major Source of MT-MMPs in IDH1-Mutant Glioma, Thus Enhancing Tumor-Cell Intrinsic Brain Infiltration.

Thome I, Lacle R, Voß A, Bortolussi G, Pantazis G, Schmidt A, Conrad C, Jacob R, Timmesfeld N, Bartsch JW, Pagenstecher A. Cancers (Basel). 2020 Aug 29;12(9):2456. doi: 10.3390/cancers12092456. PMID: 32872536 Free PMC article.

The cellular source of MT-MMPs and their role in glioma biology, however, remain controversial. Thus, we comprehensively analyzed the expression of MT-MMPs in primary brain tumors. ...However, in the OPoSSM assays, the glycosylphosphatidylinositol ( …

3

Expression and Characterization of Membrane-Type 4 Matrix Metalloproteinase (MT4-MMP) and its Different Forms in Melanoma.

Hieronimus B, Pfohl J, Busch C, Graeve L. Cell Physiol Biochem. 2017;42(1):198-210. doi: 10.1159/000477311. Epub 2017 May 25. PMID: 28531887 Free article.

BACKGROUND/AIMS: Membrane-type matrix metalloproteinases (MT-MMPs) are expressed on the cell surface and hydrolyze extracellular matrix components and signaling molecules by which they influence cancer cell migration and metastasis. Two of the six known MT …

4

Membrane-type matrix metalloproteases as diverse effectors of cancer progression.

Turunen SP, Tatti-Bugaeva O, Lehti K. Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt A):1974-1988. doi: 10.1016/j.bbamcr.2017.04.002. Epub 2017 Apr 5. PMID: 28390905 Free article. Review.

Tethered to the cell membranes by a transmembrane domain or GPI-anchor, the six MT-MMPs can exert these functions via cell surface-associated extracellular matrix degradation or proteolytic protein processing, including shedding or release of signaling …

5

Membrane-type matrix metalloproteinases: Their functions and regulations.

Itoh Y. Matrix Biol. 2015 May-Jul;44-46:207-23. doi: 10.1016/j.matbio.2015.03.004. Epub 2015 Mar 17. PMID: 25794647 Free article. Review.

Membrane-type matrix metalloproteinases (MT-MMPs) form a subgroup of the matrix metalloproteinase (MMP) family, and there are 6 MT-MMPs in humans. MT-MMPs are further sub-classified into type I transmembrane-type (MT1 …

6

Ovarian membrane-type matrix metalloproteinases: induction of MMP14 and MMP16 during the periovulatory period in the rat, macaque, and human.

Puttabyatappa M, Jacot TA, Al-Alem LF, Rosewell KL, Duffy DM, Brännström M, Curry TE Jr. Biol Reprod. 2014 Aug;91(2):34. doi: 10.1095/biolreprod.113.115717. Epub 2014 Jun 11. PMID: 24920038 Free PMC article.

Surprisingly, the periovulatory expression profile of the membrane-type matrix metalloproteinases (MT-MMPs), unique proteases anchored to the cell surface, has not been extensively examined. ...Among the six known MT-MMPs, mRNA expression …

7

Membrane-type matrix metalloproteinases: key mediators of leukocyte function.

Marco M, Fortin C, Fulop T. J Leukoc Biol. 2013 Aug;94(2):237-46. doi: 10.1189/jlb.0612267. Epub 2013 May 21. PMID: 23695309 Review.

Leukocytes express several members of the MMP family, including secreted- and membrane-anchored MT- MMPs, which synergistically orchestrate an appropriate proteolytic reaction that ultimately modulates immunological responses. ...Whereas much information exis …

8

Membrane-type 4 matrix metalloproteinase (MT4-MMP) modulates water homeostasis in mice.

Srichai MB, Colleta H, Gewin L, Matrisian L, Abel TW, Koshikawa N, Seiki M, Pozzi A, Harris RC, Zent R. PLoS One. 2011 Feb 11;6(2):e17099. doi: 10.1371/journal.pone.0017099. PMID: 21347258 Free PMC article.

MT4-MMP is a membrane-type metalloproteinase (MMP) anchored to the membrane by a glycosyl-phosphatidylinositol (GPI) motif. GPI-type MT-MMPs (MT4- and MT6-MMP) are related to other MT-MMPs, but their physiological sub …

9

MT4-(MMP17) and MT6-MMP (MMP25), A unique set of membrane-anchored matrix metalloproteinases: properties and expression in cancer.

Sohail A, Sun Q, Zhao H, Bernardo MM, Cho JA, Fridman R. Cancer Metastasis Rev. 2008 Jun;27(2):289-302. doi: 10.1007/s10555-008-9129-8. PMID: 18286233 Free PMC article. Review.

Discovered almost a decade ago, the body of work on GPI-MT-MMPs today is still surprisingly limited when compared to other MT-MMPs. However, new evidence shows that the GPI-MT-MMPs are highly expressed in human cancer, where …

10

Membrane-type 6 matrix metalloproteinase (MT6-MMP, MMP-25) is the second glycosyl-phosphatidyl inositol (GPI)-anchored MMP.

Kojima S, Itoh Y, Matsumoto S, Masuho Y, Seiki M. FEBS Lett. 2000 Sep 1;480(2-3):142-6. doi: 10.1016/s0014-5793(00)01919-0. PMID: 11034316 Free article.

This hydrophobicity pattern is similar to glycosyl-phosphatidyl inositol (GPI)-anchored MMP, MT4-MMP, and other GPI-anchored proteins. Thus, we tested the possibility that MT6-MMP was also a GPI-anchored proteinase. ...These results stron …