50,794 results
Emerging highly pathogenic H5N1 influenza triggers fibrotic remodeling in human airway organoids.
Emerg Microbes Infect. 2025 Dec;14(1):2532684. doi: 10.1080/22221751.2025.2532684. Epub 2025 Jul 25.
PMID: 40712003
In this study, we modelled infection with a highly pathogenic recombinant human A/Texas/37/2024 H5N1 (rHPh-TX H5N1) strain using human
airway organoids (HAO) to investigate viral replication, innate immune
response, infection-induced fibrogenesis, and potential ther …
Morphological and Molecular Evaluation of a Gel Based on
Hyaluronic Acid and Spermidine for Oral Regenerative Purposes.
Cells. 2025 Jul 9;14(14):1047. doi: 10.3390/cells14141047.
PMID: 40710300
BACKGROUND: Oral wound healing is a complex process influenced by extracellular matrix
(ECM) remodeling and cellular migration. Hyaluronic acid (HA) and
spermidine (SP) have shown regenerative potential, but their combined
effects on oral tissues remain unexplored. ...METH …
Dry eye-related tear biomarkers MMP-2, MMP-13, and
IFN-γ: potential predictors of Type III acute acquired concomitant
esotropia.
Eur J Med Res. 2025 Jul 24;30(1):663. doi: 10.1186/s40001-025-02941-5.
PMID: 40707963
Tethered Exosomes Containing the Matrix Metalloproteinase MT1-MMP Contribute to Extracellular Matrix Degradation.
J Extracell Vesicles. 2025 Jul;14(7):e70122. doi: 10.1002/jev2.70122.
PMID: 40704538
For cancer cells to escape from the primary tumour and
metastasize, they must degrade and navigate through the extracellular matrix (ECM). The transmembrane protease MT1-matrix metalloprotease (MMP) plays a key role in localized matrix degradation, and its ov …
D-Limonene Exhibits Antiproliferative Activity Against Human Colorectal Adenocarcinoma (Caco-2) Cells via Regulation of Inflammatory and Apoptotic Pathways.
Curr Issues Mol Biol. 2025 May 18;47(5):370. doi: 10.3390/cimb47050370.
PMID: 40699769
Free article.
This study investigated the antiproliferative potential of D-limonene, a natural compound, on human
colorectal adenocarcinoma (Caco-2) cells and analyzed its underlying
mechanisms. ...Furthermore, in a concentration-dependent way, D-limonene
therapy decreased the levels of …
Evaluation of serum and urine levels of matrix metalloproteinase (MMP-2) in children with nephrotic syndrome.
Wiad Lek. 2025;78(6):1133-1141. doi: 10.36740/WLek/204348.
PMID: 40699089
The role of matrix metalloproteinases in the modulation of aqueous humor in glaucoma patients.
Rom J Ophthalmol. 2025 Apr-Jun;69(2):208-211. doi: 10.22336/rjo.2025.33.
PMID: 40698094
Free PMC article.
Review.
Matrix metalloproteinases are crucial proteolytic enzymes involved in the degradation and remodeling of the extracellular matrix within the ocular structures. ...This review summarizes current findings on the role of matrix metalloproteinases in …
Bisphenol A suppresses colon epithelial cell responses via G0/G1-phase arrest, MAPK and PI3K/AKT pathway modulation, and MMP-2/9 Inhibition by upregulating p21WAF1.
Sci Rep. 2025 Jul 23;15(1):26698. doi: 10.1038/s41598-025-11700-9.
PMID: 40695970
Free article.
We explored the adverse effects of BPA on human
colonic epithelial cells in vitro by performing comprehensive viability,
proliferation, invasion, and migration assays on HCT 116 and HCT-8
cells. ...Furthermore, BPA treatment significantly reduced the induction
of matrix …
NFIC suppressed the epithelial ovarian cancer via
modulating the balance of PTEN/TGFbeta1/EGR1/BRD4 and SP1/EZH2 induced
Inhibition of TBX2/MMPs signaling.
Sci Rep. 2025 Jul 22;15(1):26593. doi: 10.1038/s41598-025-09653-0.
PMID: 40695900
Free article.
Additionally, TBX2 inhibits PTEN and promotes MMPs.
BRD4 promotes H3K27AC, which leads to TGFbeta1 expression, while
H3K27me3 inhibits TGFbeta1 expression. ...In vitro, NFIC inhibited the
expression of TBX2, nucleus SP1, EZH2, and MMPs, and promoted the expression o …
Basement membrane perforations guide anterior-posterior axis formation.
Nat Commun. 2025 Jul 22;16(1):6763. doi: 10.1038/s41467-025-61441-6.
PMID: 40695803
Free article.
Here, we use targeted perturbations to demonstrate that
asymmetric perforations in the basement membrane guide DVE migration.
During implantation, matrix metalloproteinases in extra-embryonic tissues create uneven basement membrane perforations, establishing directi …
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