ZNF C2H2 -type, subgroup: GLI1

 GeneCards 

GLI1, 1106  aminoacids

Recommended name:

 

Zinc finger protein GLI1 

Quaternary structure:

• Interacts with KIF7 (By similarity).
  Interacts with STK36 (PubMed:10806483).
  Interacts with ZIC1; the interaction enhances transcription activation (PubMed:11238441).
  Interacts with SUFU; this inhibits transcriptional activation by GLI1 (PubMed:10806483, 24217340, 24311597, 28965847).
• https://www.genecards.org/cgi-bin/carddisp.pl?gene=GLI1&keywords=GLI1#pathways-string

Gene Families for GLI1 Gene

HGNC:

• Zinc fingers C2H2-type

The Human Protein Atlas (HPA):

• Disease related genes
 
• Human disease related genes
 
• Predicted intracellular proteins
 
• Transcription factors

Protein Domains for GLI1 Gene

InterPro:

• Znf_C2H2_type 
 
• Znf_C2H2_sf 
 
• Znf-C2H2_ZIC1-5/GLI1-3-like 
 
• GLI-like

Blocks:

• C2H2-type zinc finger signature
  
  

  Molecular function for GLI1 Gene according to UniProtKB/Swiss-Prot

  Function:

  • Acts as a transcriptional activator (PubMed:10806483, 19706761, 19878745, 24076122, 24217340, 24311597).
    Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, 24217340, 8378770).
    Regulates the transcription of specific genes during normal development (PubMed:19706761).
    Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract.
    Mediates SHH signaling (PubMed:19706761, 28973407).
    Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, 28973407). GLI1_HUMAN,P08151
  • [Isoform 2]: Acts as a transcriptional activator, but activates a different set of genes than isoform 1.
    Activates expression of CD24, unlike isoform 1.
    Mediates SHH signaling.
    Promotes cancer cell migration. GLI1_HUMAN,P08151

  Induction:

  • Isoform 1 and isoform 2 are amplified in glioblastoma cells. GLI1_HUMAN,P08151

  Molecular function for GLI1 Gene according to GENATLAS

  Biochemistry:

  • glioma-associated oncogene homolog,with homology to Drosophila segment polarity gene Cubitus interruptus,involved in lymphomagenesis (diffuse large B cell lymphoma),acting as an activator in sonic hedgehog signaling after induction by binding of GLI3 to GLI1 promoter,interacting in a positive feedback loop with SHH in mouse limb development GLI1