Liu S, Chen H, Gagea
M, Federico L, Zhang F, Gomez J, Do KA, Symmans WF, Hortobagyi GN, Mills
GB, Gonzalez-Angulo AM, Tripathy D.Cancer Lett. 2025 Aug 28;626:217775. doi: 10.1016/j.canlet.2025.217775. Epub 2025 May 6.PMID: 40339955Free article.
The A Disintegrin and Metalloproteinase (ADAM) family
plays a vital role in cancer pathophysiology. Previous studies focused
on single ADAMmembers. However, none of these have entered into the clinical arena as diagnostics or therapeutics for breast cancer. In this …
Petitt CE, Kiracofe E, Adamson A, Barbieri JS.Dermatol Online J. 2021 Jan 15;27(1):13030/qt990631n9.PMID: 33560787Free article.
-based dermatologists (N=3,000) and the Association of Dermatology Administrators/Managers (ADAM) members
(N=718). RESULTS: Respondents reported 24% of patients require PAs.
Dermatologists and staff spend a mean of 3.3 hours/day on PAs. ...
Wang Z, Wang L, Fan R, Zhou J, Zhong J.Comput Biol Chem. 2016 Apr;61:15-22. doi: 10.1016/j.compbiolchem.2015.12.003. Epub 2015 Dec 8.PMID: 26709988
The ADAM metallopeptidase domain 17 (ADAM17 or TACE) and its close relative ADAM10 are two of the most important ADAMmembers
that share high conservation in sequence, structure and function, but
exhibit subtle difference in regulation of downstream cell signaling e …
Whelan JT, Wang L, Chen J, Metts ME, Nasser TA, McGoldrick LJ, Bridges LC.Biochem Biophys Res Commun. 2014 Nov 28;454(4):537-42. doi: 10.1016/j.bbrc.2014.10.120. Epub 2014 Oct 31.PMID: 25450689
Interestingly, adhesion occurs independent of integrin
function, and mutant studies demonstrate that atRA-induced adhesion to ADAMmembers required a distinct binding interface(s) as compared to integrin recognition. ...
Hall T, Shieh HS, Day
JE, Caspers N, Chrencik JE, Williams JM, Pegg LE, Pauley AM, Moon AF,
Krahn JM, Fischer DH, Kiefer JR, Tomasselli AG, Zack MD.Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jun 1;68(Pt 6):616-21. doi: 10.1107/S1744309112015618. Epub 2012 May 22.PMID: 22684055Free PMC article.
ADAM-8 has an overall fold similar to those of other ADAMmembers, including a central five-stranded beta-sheet and a catalytic Zn(2+) ion. ...
Ebi M, Kataoka H,
Shimura T, Kubota E, Hirata Y, Mizushima T, Mizoshita T, Tanaka M,
Mabuchi M, Tsukamoto H, Tanida S, Kamiya T, Higashiyama S, Joh T.Biochem Biophys Res Commun. 2010 Nov 19;402(3):449-54. doi: 10.1016/j.bbrc.2010.09.130. Epub 2010 Oct 8.PMID: 20934403
Membrane-anchored heparin-binding EGF-like growth factor
(proHB-EGF) ectodomain is cleaved by a disintegrin and metalloproteinase
(ADAM) members and is implicated in epidermal growth factor receptor (EGFR) transactivation. ...
Verrier S, Hogan A, McKie N, Horton M.Bone. 2004 Jul;35(1):34-46. doi: 10.1016/j.bone.2003.12.029.PMID: 15207739
In this study, we identified the expression and the regulation of ADAMmembers (a disintegrin and metalloprotease) at both gene and protein levels during human osteoclast differentiation and activity. ...
Ito N, Nomura S, Iwase A, Ito T, Kikkawa F, Tsujimoto M, Ishiura S, Mizutani S.Biochem Biophys Res Commun. 2004 Feb 20;314(4):1008-13. doi: 10.1016/j.bbrc.2003.12.183.PMID: 14751233
Immunohistochemical analysis in human placenta
demonstrated strong expression of ADAM12 in syncytiotrophoblasts, while
little expression of ADAM9 was detected throughout the placenta. Our
results suggest ADAMmembers, at least including ADAM12, are involved in P-LAP …
Rothan H, Mostafa A, Bayoumi M, Ye C, Barre RS, Allué-Guardia A, Nogales A, Torrelles JB, Martinez-Sobrido L.Emerg Microbes Infect. 2025 Dec;14(1):2532684. doi: 10.1080/22221751.2025.2532684. Epub 2025 Jul 25.PMID: 40712003
In this study, we modelled infection with a highly pathogenic recombinant human A/Texas/37/2024 H5N1 (rHPh-TX H5N1) strain using human
airway organoids (HAO) to investigate viral replication, innate immune
response, infection-induced fibrogenesis, and potential ther …
BACKGROUND: Oral wound healing is a complex process influenced by extracellular matrix
(ECM) remodeling and cellular migration. Hyaluronic acid (HA) and
spermidine (SP) have shown regenerative potential, but their combined
effects on oral tissues remain unexplored. ...METH …
Palmulli R, Jackson HK, Edgar JR.J Extracell Vesicles. 2025 Jul;14(7):e70122. doi: 10.1002/jev2.70122.PMID: 40704538
For cancer cells to escape from the primary tumour and
metastasize, they must degrade and navigate through the extracellular matrix (ECM). The transmembrane protease MT1-matrix metalloprotease (MMP) plays a key role in localized matrix degradation, and its ov …
This study investigated the antiproliferative potential of D-limonene, a natural compound, on human
colorectal adenocarcinoma (Caco-2) cells and analyzed its underlying
mechanisms. ...Furthermore, in a concentration-dependent way, D-limonene
therapy decreased the levels of …
Matrixmetalloproteinases are crucial proteolytic enzymes involved in the degradation and remodeling of the extracellular matrix within the ocular structures. ...This review summarizes current findings on the role of matrixmetalloproteinases in …
Song JH, Lee D, Hwang B, Kim S, Kim J, Park S, Choo S, Hwang SK, Kim H, Yun SJ, Choi YH, Kim WJ, Moon SK.Sci Rep. 2025 Jul 23;15(1):26698. doi: 10.1038/s41598-025-11700-9.PMID: 40695970Free article.
We explored the adverse effects of BPA on human
colonic epithelial cells in vitro by performing comprehensive viability,
proliferation, invasion, and migration assays on HCT 116 and HCT-8
cells. ...Furthermore, BPA treatment significantly reduced the induction
of matrix …
Ren Y, Xu R, Zhang D, Su L, Jin Y, Li N, Wang Y.Sci Rep. 2025 Jul 22;15(1):26593. doi: 10.1038/s41598-025-09653-0.PMID: 40695900Free article.
Additionally, TBX2 inhibits PTEN and promotes MMPs.
BRD4 promotes H3K27AC, which leads to TGFbeta1 expression, while
H3K27me3 inhibits TGFbeta1 expression. ...In vitro, NFIC inhibited the
expression of TBX2, nucleus SP1, EZH2, and MMPs, and promoted the expression o …
Chen DY, Claussen NH, Titus S, Hu W, Weatherbee BAT, Mandelbaum RS, Scott RT Jr, Seli E, Streichan SJ, Zernicka-Goetz M.Nat Commun. 2025 Jul 22;16(1):6763. doi: 10.1038/s41467-025-61441-6.PMID: 40695803Free article.
Here, we use targeted perturbations to demonstrate that
asymmetric perforations in the basement membrane guide DVE migration.
During implantation, matrixmetalloproteinases in extra-embryonic tissues create uneven basement membrane perforations, establishing directi …
Muñoz-Sáez E, Moracho N, Learte AIR, Collignon A, Arroyo AG, Noel A, Sounni NE, Sánchez-Camacho C.Int J Mol Sci. 2023 Jun 9;24(12):9944. doi: 10.3390/ijms24129944.PMID: 37373092Free PMC article.Review.
MT4-MMP (or MMP-17) belongs to the membrane-type matrix metalloproteinases (MT-MMPs), a distinct subset of the MMP family that is anchored to the cell surface, in this case by a glycosylphosphatidylinositol (GPI) motif. ...
Thome I, Lacle R, Voß A, Bortolussi G, Pantazis G, Schmidt A, Conrad C, Jacob R, Timmesfeld N, Bartsch JW, Pagenstecher A.Cancers (Basel). 2020 Aug 29;12(9):2456. doi: 10.3390/cancers12092456.PMID: 32872536Free PMC article.
The cellular source of MT-MMPs and their role in glioma biology, however, remain controversial. Thus, we comprehensively analyzed the expression of MT-MMPs in primary brain tumors. ...However, in the OPoSSM assays, the glycosylphosphatidylinositol ( …
BACKGROUND/AIMS: Membrane-type matrix metalloproteinases (MT-MMPs)
are expressed on the cell surface and hydrolyze extracellular matrix
components and signaling molecules by which they influence cancer cell
migration and metastasis. Two of the six known MT …
Tethered to the cell membranes by a transmembrane domain or GPI-anchor, the six MT-MMPs
can exert these functions via cell surface-associated extracellular
matrix degradation or proteolytic protein processing, including shedding
or release of signaling …
Membrane-type matrix metalloproteinases (MT-MMPs) form a subgroup of the matrix metalloproteinase (MMP) family, and there are 6 MT-MMPs in humans. MT-MMPs are further sub-classified into type I transmembrane-type (MT1 …
Puttabyatappa M, Jacot TA, Al-Alem LF, Rosewell KL, Duffy DM, Brännström M, Curry TE Jr.Biol Reprod. 2014 Aug;91(2):34. doi: 10.1095/biolreprod.113.115717. Epub 2014 Jun 11.PMID: 24920038Free PMC article.
Surprisingly, the periovulatory expression profile of the membrane-type matrix metalloproteinases (MT-MMPs), unique proteases anchored to the cell surface, has not been extensively examined. ...Among the six known MT-MMPs, mRNA expression …
Marco M, Fortin C, Fulop T.J Leukoc Biol. 2013 Aug;94(2):237-46. doi: 10.1189/jlb.0612267. Epub 2013 May 21.PMID: 23695309Review.
Leukocytes express several members of the MMP family, including secreted- and membrane-anchoredMT- MMPs,
which synergistically orchestrate an appropriate proteolytic reaction
that ultimately modulates immunological responses. ...Whereas much
information exis …
Srichai MB, Colleta H, Gewin L, Matrisian L, Abel TW, Koshikawa N, Seiki M, Pozzi A, Harris RC, Zent R.PLoS One. 2011 Feb 11;6(2):e17099. doi: 10.1371/journal.pone.0017099.PMID: 21347258Free PMC article.
MT4-MMP is a membrane-type metalloproteinase (MMP) anchored to the membrane by a glycosyl-phosphatidylinositol (GPI) motif. GPI-typeMT-MMPs (MT4- and MT6-MMP) are related to other MT-MMPs, but their physiological sub …
Sohail A, Sun Q, Zhao H, Bernardo MM, Cho JA, Fridman R.Cancer Metastasis Rev. 2008 Jun;27(2):289-302. doi: 10.1007/s10555-008-9129-8.PMID: 18286233Free PMC article.Review.
Discovered almost a decade ago, the body of work on GPI-MT-MMPs today is still surprisingly limited when compared to other MT-MMPs. However, new evidence shows that the GPI-MT-MMPs are highly expressed in human cancer, where …
Kojima S, Itoh Y, Matsumoto S, Masuho Y, Seiki M.FEBS Lett. 2000 Sep 1;480(2-3):142-6. doi: 10.1016/s0014-5793(00)01919-0.PMID: 11034316Free article.
This hydrophobicity pattern is similar to glycosyl-phosphatidyl inositol (GPI)-anchored MMP, MT4-MMP, and other GPI-anchored proteins. Thus, we tested the possibility that MT6-MMP was also a GPI-anchored proteinase. ...These results stron …
28.7.2025. klo00:14 Asetan tähän edellisen listan lisäksi tulleet sekä summan artikkelista, jotka koskevat tätä proteiiniperhettä: PubMed on juuri päivittänyt tietueensa 24.7.2025.
Karasu U, Erkek M, Ulutaş F, Demiray A, Çimen Y, Kaymaz S, Açıkbaş İ, Şenol H, Çobankara V.Mediterr J Rheumatol. 2024 Nov 7;36(1):73-78. doi: 10.31138/mjr.020524.pla. eCollection 2025 Mar.PMID: 40557182Free PMC article.
We hypothesised that decreased activity or increased inhibitor levels of ADAMTS-13 may cause increased levels of VWF. Therefore, we investigated ADAMTS-13 in patients with BD. ...Parametric data with normal distribution were compared with Student's t-test and ANOVA, …
Zhang K, Chen Z, Gao C, Li X, Wang N, Zhang M, Yan H, Sha Z, Chen S.Int J Mol Sci. 2025 Jun 2;26(11):5346. doi: 10.3390/ijms26115346.PMID: 40508155Free PMC article.
All genes possessed a conserved ZP domain, characteristic of the gene family
from mammals to teleosts. Among them, nine genes were highly expressed
in ovary cells, with the expression levels increasing during ovarian
development, while another three genes were predominantl …
Alper M, Sav FN, Keleş Y, Eroğlu KP, Keskin SD, Köçkar F.Mol Biol Rep. 2025 Feb 19;52(1):246. doi: 10.1007/s11033-025-10342-4.PMID: 39969607
BACKGROUND: ADAMTSs are extracellular matrix
metalloproteinases that mainly process extracellular matrix components
and closely related tumorigenesis. ADAMTS-8 is an anti-angiogenic member of the family and is dysregulated in common cancers. ...STATs, Elk-1, and c-J …
The methylation degree of promoter regions in genes encoding ADAMTSfamily
proteins could significantly influence LUSC and LUAD. Increased
promoter methylation could also reduce certain gene expression,
contributing to cancer progression. ...Further research is need …
Chen S, He J, Gao H, Gao X, Dai L, Chen J, Sha Z.J Cancer. 2025 Jan 1;16(3):1008-1019. doi: 10.7150/jca.103093. eCollection 2025.PMID: 39781347Free PMC article.
The ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family
of metalloproteinases plays a vital role in various biological and
pathological processes, including tissue remodeling, angiogenesis, and
cancer progression. Among the 19 ADAMTS …
Xiao L, Li Q, Chen S, Huang Y, Ma L, Wang Y, Chen J, Zhang J, Liu A, Yuan X, Liu Y, Liu B.Cell Death Dis. 2024 Nov 17;15(11):837. doi: 10.1038/s41419-024-07226-z.PMID: 39551781Free PMC article.
The poor prognosis of LUAD patients is attributed primarily to metastasis. ADAMTS16 is a crucial member of the ADAMTSfamily and is involved in tumor progression. However, its role and regulatory mechanism in LUAD remain unexplored. ...
Chen Y, Xiao C, Fan Q, Zhang Y, Huang Q, Ou Y.Front Biosci (Landmark Ed). 2024 Apr 12;29(4):151. doi: 10.31083/j.fbl2904151.PMID: 38682182Free article.
The roles of another important group: the ADAMs with thrombospondin motifs (ADAMTS) remain unclear. This study aimed to perform a pan-cancer analysis of procollagen N-propeptidase subgroup of ADAMTS (PNPSA). ...Single-cell sequencing analysis reveals expressions of …
The present study examines the relationship between circular RNA (circRNA) derived from three genes of the family
a disintegrin and metalloproteinase with thrombospondin motifs
(ADAMTSs): ADAMTS6, ADAMTS9 and ADAMTS12 and the host gene expression in
non-small-cell lung can …
Minns AF, Santamaria S.Methods Mol Biol. 2024;2747:83-93. doi: 10.1007/978-1-0716-3589-6_8.PMID: 38038934
Metalloproteinases of the A Disintegrin and Metalloproteinase with Thrombospondin-like motif (ADAMTS) family
cleave versican at a specific Glu-Ala bond, thus releasing a bioactive
fragment named versikine, whose biological function, still not entirely
revealed, seem …
So far, the only reported substrate for ADAMTS8 is
osteopontin (OPN), an extracellular matrix protein widely implicated in
multiple steps of cancer progression, albeit, similar to other ADAMTSfamily members, it is very likely that ADAMTS8 cleaves a variety of subst …
Silva SV, Lima MA, Hodgson L, Freitas VM, Rodríguez-Manzaneque JC.Exp Cell Res. 2023 Dec 15;433(2):113852. doi: 10.1016/j.yexcr.2023.113852. Epub 2023 Nov 10.PMID: 37951335Free PMC article.
However, our research specifically detected ADAMTS-1, a member of this family, predominantly within the nucleus of mammary cells. Our main objective was to understand the mechanism of ADAMTS-1 translocation to the nucleus and its functional significance in th …
