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fredag 13 januari 2012

Angiogeneesin säätely silmässä

Angiogeneesistä uusi väitöskirja. MMP osallistuu angiogeneesin säätelyyn.Oftalmologian alalta väitöskirja.

Bourghardt Peebo, Beatrice. Angiogenesis from a new perspective Linköpings universitet Institutionen för klinisk och experimentell medicin. Oftalmologi. 
ISBN 978-91-7519-999-3
Linköping : Linköping University Electronic Press, 2012
English 91 s.
Series: Linköping University Medical Dissertations, 0345-0082 ; 1284
Read full text (fulltext)
  • Doctoral thesis (other academic)
Abstract Subject headings
Background 
Sitaatti: 
Huomaa MMP  ja TIMP  joukossa. 
Activators  Function
  • VEGF family members Stimulate vasculogenesis/angiogenesis, permeability, leukocyte adhesion
  • Angiopoietin1, Tie2 Stabilize vessels, inhibit permeability
  • PDGF Recruit pericytes, smooth muscle cells
  • TGF-ß1, endoglin, TGF-ß-receptors Stimulate ECM production, recruit macrophages
  • FGF, HGF, MCP1 Stimulate angio/arterogenesis
  • Integrins Receptor for matrix macromolecules, proteinases
  • VE-cadherin, PECAM (CD31)  Endothelial junctional molecules
  • Plasminogen activators, MMPs  Remodel ECM, release and activate growth factors
  • NOS-COX2 Stimulate angiogenesis and vasodilation
  • HIF-1 Activates VEGF and other pro-angiogenic factors
Inhibitors Function
  • VEGFR-1, soluble VEGFR-1, VEGFR-3 Sink for VEGF, PlGF
  • Angiopoietin2 Antagonist for Angiopoietin1
  • Trombospondin1,-2 Inhibit endothelial migration, growth, adhesion and survival
  • Angiostatin Suppress tumor angiogenesis
  • Endostatin (collagen XVIII fragment) Inhibit endothelial survival and migration
  • TIMP InhibitsMMP
  • IL-4, IL-12, IL-8, IFN-α,-ß,-ƴ Inhibit endothelial migration, down regulatebFGF
Table 1. Examples of activators and inhibitors of angiogenesis and their known func-
tions. (Carmeliet et al 2000)

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