Niillä voi olla jokin muu oma funktio kuin vain olla MMPi.
https://www.genenames.org/cgi-bin/genefamilies/set/892
Tissue inhibitor of metalloproteinase: The matrix
metalloproteinases are inhibited by specific endogenous tissue
inhibitors of metalloproteinases (TIMPs), which comprise a family of
four protease inhibitors: TIMP1, TIMP2, TIMP3 and TIMP4.
Overall, all MMPs are inhibited by TIMPs once they are activated but the
gelatinases (MMP-2 and MMP- ) can form complexes with TIMPs when the
enzymes are in the latent form. The complex of latent MMP-2
(pro-MMP-2)with TIMP-2 serves to facilitate the activation of pro-MMP-2
at the cell surface by MT1-MMP ( MMP-14 ), a membrane-anchored MMP. The
role of the pro-MMP-9/TIMP-1 complex is still unknown.
[Source: Wikipedia]
Genes contained within the family: 4
| l | TIMP1 | TIMP1 metallopeptidase inhibitor 1 EPO, (Xp11.3) | TIMP2 | TIMP 2metallopeptidase inhibitor 2 CSC-21K (17q25.3) | TIMP3 | TIMP3 metallopeptidase inhibitor 3 SFD (22q12.3) | TIMP4 | TIMP4 metallopeptidase inhibitor 4 |
|---|
TIMP-1
Function
Metalloproteinase inhibitor that
functions by forming one to one complexes with target
metalloproteinases, such as collagenases, and irreversibly inactivates
them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2,
MMP3, MMP7, MMP8, P9, MMP10, MMP11, MMP12,
MMP13 and MMP16. Does not act on MMP14. Also functions as a growth
factor that regulates cell differentiation, migration and cell death and
activates cellular signaling cascades via CD63 and ITGB1. Plays a role
in integrin signaling. Mediates erythropoiesis in vitro; but, unlike
IL3, it is species-specific, stimulating the growth and differentiation
of only human and murine erythroid progenitors.12 Publications
TIMP-2
TIMP-3
A
novel function for tissue inhibitor of metalloproteinases-3 (TIMP3):
inhibition of angiogenesis by blockage of VEGF binding to VEGF
receptor-2.
Qi JH et al. Nat. Med. 2003 Apr;9(4):407-415
PMID: 12652295 Europe PMC Pubmed
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